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Pepirine caps


EasyMoneySnip3r
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EasyMoneySnip3r

Heard good things 

 

anybody give it ago 

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porkandbeansboy
Posted (edited)

@EasyMoneySnip3r For what purpose exactly? Pipirine is commonly used as a P-Glyco Protein Inhibitor to make specific drugs stronger.

Edited by porkandbeansboy
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EasyMoneySnip3r

@porkandbeansboy yeah to enhance turmeric and such 

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BrokenLeashesAllOverTheFloor

Also known as black pepper extract, biopepine, and a couple other names. 10mg = about 1/4 teaspoon of black pepper. 

It increases the secretion of digestive enzymes so supps/nutrients/vitamins/etc breakdown faster, thereby increasing bioavailability. 

Works great with turmeric (~2000% increase in bioavailability, if I remember correctly). 

Also works with, kratom, adderall, nootropics, nutrient-rich foods in general, coffee, green and black tea, apple cider vinegar... just about everything. 

People that have problems absorbing nutrients take it to increase the effectiveness of therapeutic drugs. It's also why black pepper with spinach, asparagus, broccoli, and brussel sprouts is so damn good. 

I've found it most effective if taken with a small amount of high carb/high fat warm foods like rice and butter; they will cause your body to send more blood to your stomach, further enhancing the effects. Ginger ale (real ginger ale—like Seagrams, not the cheap generic crap) also enhances its effects.

It's been amazing in my experience. 

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If you're using it for P-glyco protein inhibition stronger and easier more practical options to use are. Proton Pump Inhibitors. Read how PPIs like (stomach acid reducers) Omeprazole or Pantoprazole for example not sure the strongest one is for P-gp Inhibition. It's especially good for something like Adder0l (0pi0ids too) where lowering stomach acidity also increases absorption too for example. Stomach Acid reducers will decrease absorption of vitamins+other supplements @BrokenLeashesAllOverTheFloor mentioned in fact long-term use of stomach acid reducers can cause vitamin/mineral deficiencies due to not enough stomach acid.


The flavonoid supplement Quercetin is known to be a strong P-gp inhibitor too. It's sold as a herbal supplement used for various reasons. Bromelain+Vitamin C increase it's low oral bioavailability. Combining other flavonoids like those in Grapefruit Juice helps too. More than 1000mg of Quercetin daily long-term will cause kidney damage keep that in mind. It's a strong CYP3A4 and CYP1A2 Inhibitor too. If that's a concern for you unlike Omeprazole (Prilosec) which Inhibits CYP3A4 and CYP2C19 Pantoprazole (Tecta) doesn't.


There are others I think. I can't remember right now I'm so sleepy.

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strungoutinheaven

@porkandbeansboy Thanks for that primer- you’re a wealth of information on this subject! Any insights into  boosting enzyme efficacy, for example CYP2D6 in metabolism of codeine & tramadol? Or any other biochem hacks up your sleeve? 

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